|Title||Sensory Innervation of the Female Human Umbilical Skin: Morphological Studies.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Saad El-Dien, HM, Abdelwahed Hussein MR, El-Oteify M|
|Date Published||2011 Aug 15|
Background: Sensory stimuli are conducted by several cutaneous sensory nerves and tactile corpuscles. The latter are specialized sensory organs that represent the starting point of many afferent sensory pathways. To date, our knowledge about the distribution of the sensory innervation in the umbilical skin of females is incomplete. Aim of the study: To elucidate the morphology of the cutaneous innervation of the normal female umbilical skin. Materials and methods: Biopsies of normal umbilical skin were obtained from female patients undergoing umbilical hernial repair. The specimens were processed for both immunohistological (antibodies against PGP9.5, pan-neuronal marker, and S-100 protein, marker of Schwann cells) and ultrastructural (transmission electron microscopy) examinations. Results: The authors found abundant genital end-bulb-like structures, numerous epidermal and dermal Merkel cells, Meissner and Ruffini corpuscles, intraepidermal nerve terminals, and multiple free nerve endings surrounding the ducts and acini of the sweat glands. Conclusions: The umbilical skin of females has abundant sensory innervation similar to that of the glans penis.
|Short Title||Ultrastruct Pathol|